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KMID : 0615720120290060073
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Jouranl of Korean Acupuncture and Moxibustion society
2012 Volume.29 No. 6 p.73 ~ p.83
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The Effect of Junci Medulla Herbal-acupuncture at KI10 on LPS induced Nephritis in Rats
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Ihm Jee-Soon
Cho Tae-Hwan
Yim Yun-Kyoung
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Abstract
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Objectives : This study aimed to evaluate the effects of Junci Medulla Herbal-acupuncture(JM-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods : Rats with nephritis induced by LPS, were treated with JM-HA at KI10 3 times a week. The rats in the NP group and the saline group were treated with a needle prick and a saline injection respectively. To evaluate the effects of JM-HA at KI10 on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine, TNF-α in serum, creatinine, total protein in urine and renal MPO were measured.
Results : JM-HA at KI10 significantly inhibited the increase of WBC and neutrophils in blood, BUN, creatinine, TNF-α in serum, and MPO in kidney of LPS-stimulated rats.
Conclusion : JM-HA at KI10 has therapeutic effects on nephritis in LPS-stimulated rats. Therefore, it is suggested that JM-HA at KI10 may be a useful therapy in clinical field after further researches.
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KEYWORD
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nephritis, herbal-acupuncture, KI10, Junci Medulla, LPS
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